{"id":4652,"date":"2021-10-05T16:04:17","date_gmt":"2021-10-05T14:04:17","guid":{"rendered":"https:\/\/nanexa.com\/?page_id=4652"},"modified":"2022-05-24T21:36:37","modified_gmt":"2022-05-24T19:36:37","slug":"discover-the-story","status":"publish","type":"page","link":"https:\/\/nanexa.com\/sv\/discover-the-story\/","title":{"rendered":"Discover the story<\/span>"},"content":{"rendered":"

For professionals in electronics and materials manufacturing Atomic Layer Deposition technology (ALD) has long been highly valued. ALD is a precise, conformal and customizable nanoscale film coating used to protect and extend the life of many of the world\u2019s most advanced industrial electronics and semiconductor products.<\/p>\n

So what if the technology could be used to coat the Active Pharmaceutical Ingredients (APIs) in drugs? A customized film coating of slow-dissolving inorganic oxides encasing the organic API would enable the controlled dissolution of the API into the bloodstream, over days, weeks or months – protecting and stabilizing the API, and extending treatment and effect. This was the intriguing proposal raised by Anders Johansson and M\u00e5rten Rooth, Nanexa\u2019s. co-founders, at a meeting with a big pharma company in 2013.<\/p>\n

BUT WOULD IT WORK?<\/h3>\n

\u201cWe\u2019d been working on ALD in medical devices when the idea of applying it to APIs first came up. The clients explained their challenges with drug delivery, and we began thinking \u2018what if we could use an ALD coating for actual medicine, as well as medical equipment\u2019.<\/p>\n

\u201cWe\u2019d had mixed results in our medical device projects \u2013 but early on with the pharma development we realized \u2018we\u2019ve really got something here, this could work. It will be hard, but we can do it\u2019 – and eventually we did.\u201d<\/p>\n

The patent for the first ALD-encased API was filed in 2013. Today the first clinical study using a PharmaShell\u00ae, ALD-encased pharmaceutical is underway, with others in the pipeline.<\/p>\n

\u2018FIRST IN THE FIELD\u2019<\/h3>\n

What were the biggest challenges? \u201cAgglomeration. We worked with a lot of substances and kept hitting the wall. Being first in the field though meant that we weren\u2019t fazed, we solved each problem as it arose, we knew this was new territory.<\/p>\n

\u201cIn the end solving agglomeration was at the heart of our patent and our process. It\u2019s what makes PharmaShell\u00ae unique. We build up the shell in repeated layers, coating then sieving until each particle is sealed tight. It\u2019s an ambient process, no solvents, and allows for high drug loads, (up to 80%). It gives exceptional control of the thickness of the coating, enabling great versatility, and making it possible to coastwise a wide range of APIs including biologics, proteins and peptides.\u201d<\/p>\n

LONG-ACTING INJECTABLES INTO THE FUTURE<\/h3>\n

Long-Acting Injectables have big implications, potentially increasing the tolerability of drugs, reducing the number of injections needed in existing long-term treatment regimens and enabling the development of novel therapies. What of the future of ALD and PharmaShell\u00ae as a pharmaceutical formulation method?<\/p>\n

\u201cI think it will grow. Today, with injectable APIs, you administer the shot, there is an immediate effect \u2013 but then the API vanishes quickly into the bloodstream. Being able to prevent that from happening, creating a depot with a tight controllable coating, opens up a lot of possibilities in terms of extending a treatment\u2019s price, effect and value.\u201d<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

For professionals in electronics and materials manufacturing Atomic Layer Deposition technology (ALD) has long been highly valued. ALD is a precise, conformal and customizable nanoscale film coating used to protect and extend the life of many of the world\u2019s most advanced industrial electronics and semiconductor products.<\/p>\n

L\u00e4s mer<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template.story.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-4652","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nDiscover the story - Nanexa AB<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nanexa.com\/discover-the-story\/\" \/>\n<meta property=\"og:locale\" content=\"sv_SE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Discover the story - Nanexa AB\" \/>\n<meta property=\"og:description\" content=\"For professionals in electronics and materials manufacturing Atomic Layer Deposition technology (ALD) has long been highly valued. ALD is a precise, conformal and customizable nanoscale film coating used to protect and extend the life of many of the world\u2019s most advanced industrial electronics and semiconductor products.L\u00e4s mer\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nanexa.com\/discover-the-story\/\" \/>\n<meta property=\"og:site_name\" content=\"Nanexa AB\" \/>\n<meta property=\"article:modified_time\" content=\"2022-05-24T19:36:37+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Ber\u00e4knad l\u00e4stid\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minuter\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/nanexa.com\\\/discover-the-story\\\/\",\"url\":\"https:\\\/\\\/nanexa.com\\\/discover-the-story\\\/\",\"name\":\"Discover the story - Nanexa AB\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/nanexa.com\\\/#website\"},\"datePublished\":\"2021-10-05T14:04:17+00:00\",\"dateModified\":\"2022-05-24T19:36:37+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/nanexa.com\\\/discover-the-story\\\/#breadcrumb\"},\"inLanguage\":\"sv-SE\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/nanexa.com\\\/discover-the-story\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/nanexa.com\\\/discover-the-story\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Hem\",\"item\":\"https:\\\/\\\/nanexa.com\\\/sv\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Discover the story\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/nanexa.com\\\/#website\",\"url\":\"https:\\\/\\\/nanexa.com\\\/\",\"name\":\"Nanexa AB\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/nanexa.com\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/nanexa.com\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"sv-SE\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/nanexa.com\\\/#organization\",\"name\":\"Nanexa AB\",\"url\":\"https:\\\/\\\/nanexa.com\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"sv-SE\",\"@id\":\"https:\\\/\\\/nanexa.com\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/nanexa.com\\\/wp-content\\\/uploads\\\/2015\\\/04\\\/nanexa-logo.png\",\"contentUrl\":\"https:\\\/\\\/nanexa.com\\\/wp-content\\\/uploads\\\/2015\\\/04\\\/nanexa-logo.png\",\"width\":165,\"height\":50,\"caption\":\"Nanexa AB\"},\"image\":{\"@id\":\"https:\\\/\\\/nanexa.com\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Discover the story - Nanexa AB","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/nanexa.com\/discover-the-story\/","og_locale":"sv_SE","og_type":"article","og_title":"Discover the story - Nanexa AB","og_description":"For professionals in electronics and materials manufacturing Atomic Layer Deposition technology (ALD) has long been highly valued. ALD is a precise, conformal and customizable nanoscale film coating used to protect and extend the life of many of the world\u2019s most advanced industrial electronics and semiconductor products.L\u00e4s mer","og_url":"https:\/\/nanexa.com\/discover-the-story\/","og_site_name":"Nanexa AB","article_modified_time":"2022-05-24T19:36:37+00:00","twitter_card":"summary_large_image","twitter_misc":{"Ber\u00e4knad l\u00e4stid":"2 minuter"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/nanexa.com\/discover-the-story\/","url":"https:\/\/nanexa.com\/discover-the-story\/","name":"Discover the story - Nanexa AB","isPartOf":{"@id":"https:\/\/nanexa.com\/#website"},"datePublished":"2021-10-05T14:04:17+00:00","dateModified":"2022-05-24T19:36:37+00:00","breadcrumb":{"@id":"https:\/\/nanexa.com\/discover-the-story\/#breadcrumb"},"inLanguage":"sv-SE","potentialAction":[{"@type":"ReadAction","target":["https:\/\/nanexa.com\/discover-the-story\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/nanexa.com\/discover-the-story\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Hem","item":"https:\/\/nanexa.com\/sv\/"},{"@type":"ListItem","position":2,"name":"Discover the story"}]},{"@type":"WebSite","@id":"https:\/\/nanexa.com\/#website","url":"https:\/\/nanexa.com\/","name":"Nanexa AB","description":"","publisher":{"@id":"https:\/\/nanexa.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/nanexa.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"sv-SE"},{"@type":"Organization","@id":"https:\/\/nanexa.com\/#organization","name":"Nanexa AB","url":"https:\/\/nanexa.com\/","logo":{"@type":"ImageObject","inLanguage":"sv-SE","@id":"https:\/\/nanexa.com\/#\/schema\/logo\/image\/","url":"https:\/\/nanexa.com\/wp-content\/uploads\/2015\/04\/nanexa-logo.png","contentUrl":"https:\/\/nanexa.com\/wp-content\/uploads\/2015\/04\/nanexa-logo.png","width":165,"height":50,"caption":"Nanexa AB"},"image":{"@id":"https:\/\/nanexa.com\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/nanexa.com\/sv\/wp-json\/wp\/v2\/pages\/4652","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanexa.com\/sv\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/nanexa.com\/sv\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/nanexa.com\/sv\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nanexa.com\/sv\/wp-json\/wp\/v2\/comments?post=4652"}],"version-history":[{"count":20,"href":"https:\/\/nanexa.com\/sv\/wp-json\/wp\/v2\/pages\/4652\/revisions"}],"predecessor-version":[{"id":6444,"href":"https:\/\/nanexa.com\/sv\/wp-json\/wp\/v2\/pages\/4652\/revisions\/6444"}],"wp:attachment":[{"href":"https:\/\/nanexa.com\/sv\/wp-json\/wp\/v2\/media?parent=4652"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}